WebApr 6, 2024 · Cisplatin (Platinol) is an inorganic coordination complex with a broad range of antitumor activity. It is especially useful in the treatment of testicular and ovarian cancer. It binds to DNA at nucleophilic sites, such as the N7 and O6 of guanine, producing alterations in DNA structure and inhibition of DNA synthesis. WebA half-life of 2 hours was observed in cell extracts of two different cancer cell lines (colon carcinoma and human mesothelioma), which was significantly shorter than that observed …
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WebSep 7, 2024 · The anticancer drug cisplatin hydrolyzes in water with a rate constant of 1.5 × 10 −3 min −1 at pH 7.0 and 25°C. Calculate the half-life for the hydrolysis reaction under these conditions. If a freshly prepared solution of cisplatin has a concentration of 0.053 M, what will be the concentration of cisplatin after 5 half-lives? after 10 half-lives? WebWorldwide, the number of cancer-related deaths continues to increase due to the ability of cancer cells to become chemotherapy-resistant and metastasize. For women with ovarian cancer, a staggering 70% will become resistant to the front-line therapy, cisplatin. Although many mechanisms of cisplatin resistance have been proposed, the key mechanisms of … porsche boyfriend
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WebA half-life of 2 hours was observed in cell extracts of two different cancer cell lines (colon carcinoma and human mesothelioma), which was significantly shorter than that observed in sodium chloride. Hence, it was suggested that intact and nonaquated cisplatin was reacting with cellular components. WebNov 1, 2024 · The terminal half-life of Furosemide is approximately 2 hours. ... There is a risk of ototoxic effects if cisplatin and Furosemide are given concomitantly. In addition, nephrotoxicity of nephrotoxic drugs such as cisplatin may be enhanced if Furosemide is not given in lower doses and with positive fluid balance when used to achieve forced ... WebDec 4, 2024 · Half-lives linpk makes it quite easy to access some secondary parameters from the PK model and simulation. The half-lives of the model can be obtained directly using the halflife () function. For instance for the 3-compartment model with first-order absorption in the previous section: porsche brake caliper rebuild service