Ptf1a-creert2

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August undefined, 2024

WebJan 5, 2016 · To inactivate Bptf to analyse its role in c-MYC-driven pancreatic tumorigenesis, we administered 25 mg of tamoxifen (Sigma-Aldrich, T-5648) by gavage over the course of 1 week to 5–7-week-old Bptf lox/lox;Ptf1a-CreERT2 +/KI;Ela1-Myc mice and their corresponding controls. Mice were screened for pancreatic tumours once a week using a … WebPtf1a-CreERT2, Ptf1a em1(CreERT2-WPRE-pA)Smoc Gene: Ptf1a Location: Chr2:19450474-19452312 bp, + strand Genetic Position: Chr2, 13.37 cM, cytoband A2

Ptf1a-CreERT2

WebA CreERT2-WPRE-pA expression cassette was knocked into the Ptf1a gene start codon site. Research Application ：These mice express cre recombinase from the Ptf1a locus. By … http://www.informatics.jax.org/allele/MGI:6758049 bubble sounds in radiator

Mouse models of Kras activation in gastric cancer

WebDownload scientific diagram Pdx1 and Ptf1a transcription factors control early steps of pancreas specification. a Wholemount immunofluorescence for Pdx1 in an E10.5 mouse embryo revealing the ... WebJan 1, 2024 · Ptf1a CreERTM, 16 CK19 CreERT2, 17 Sox9-CreERT2, 23 LSL-Kras G12D, 15 and R26R EYFP 18 mice have been described previously. Cre-mediated recombination … Webcerebellar cortex. The data in Figure S1 also demonstrate that Ptf1a+ cells in the PWM, which we show respond to Shh, contribute exclusively to GABAergic interneurons. Figure S2. Figure S2 provides important results from our Gli1 fate-mapping studies that are essential to our interpretation of the data presented in Figure 2. export music premieere pro settings youtube

Hes1 plays an essential role in Kras -driven pancreatic ... - Nature

PTF1A pancreas associated transcription factor 1a [ (human)]

WebMar 1, 2024 · Corresponding mouse lineage-tracing studies using Cpa1 CreERT2 and Ptf1a CreERTM also revealed a shift from multipotency to acinar-specific unipotency after secondary transition (Zhou et al., 2007), while multipotency was found to be (re)activated in Ptf1a + cells by injury, e.g. partial duct ligation (Pan et al., 2013). WebNov 11, 2013 · This observation was surprising given that Ptf1a + cells in the embryonic cerebellum are exclusively postmitotic (Huang et al., 2010). To assess whether Ptf1a + cells generate Pax2 + cells, we performed GIFM experiments using a Ptf1a CreERT2 knockin driver (Pan et al., 2013) paired with R26R eYFP mice to which tamoxifen (TM) was … export music frm iphone to mac freeWebBPTF in young Ela-Myc via activation of the Ptf1a-CreERT2 recombinase results in a significant delay in tumor onset and a corresponding extension in disease-free survival. c-MYC overexpression in the B cell lineage (E -Myc) leads to the development of Burkitt-like lymphomas. Inactivation of one Bptf allele does not bubbles out of pool jets

"WebAs predicted, PTF1a induced gene expression of digestive enzymes and acinar-specific transcription factors, while MIST1 induced gene expression of vesicle trafficking … " - Ptf1a-creert2

Ptf1a-creert2

Mouse models of Kras activation in gastric cancer Experimental ...

Web036577 B6.129S6(Cg)- Ptf1a tm2(cre/ESR1)Cvw /J The Ptf1a Cre-ERTM knock-in allele was designed to both abolish pancreas specific transcription factor, 1a ( Ptf1a ) gene function and express CreERTM fusion protein from the Ptf1a promoter/enhancer elements. PTF1A effects growth and lineage specification of pancreatic multipotent progenitor cells during … WebJan 31, 2024 · We believe that these differences are due to the difference of Cre-inducing mouse used for Hes1 ablation, i.e., Elastase1-CreERT2 mice in our work and Ptf1a-Cre in …

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WebPTF1A effects growth and lineage specification of pancreatic multipotent progenitor cells during development. This strain has been replaced by a C57BL/6J congenic version as …

WebHowever, to date it has remained unclear whether, as in mammals, ptf1a-expressing zebrafish pancreatic progenitors are able to contribute to multiple exocrine and endocrine lineages. To delineate the lineage potential of ptf1a-expressing cells, we generated ptf1a:creERT2 transgenic fish and performed genetic-inducible Developmental Dynamics WebFig.1 CreERT2-mediated recombination in the pancreas of Ptf1aCreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the pancreatic …

Web图 2 Tamoxifen 诱导后，Ptf1a CreERT2/+; Rosa26 tdTomato/+ 小鼠各组织中tdTomato的表达情况。. CreERT2重组酶的活性特异表达在胰腺腺泡，有少量细胞漏表达；在小脑、垂体和胃粘膜下层有极少量细胞表达。. 未检测到表达的组织包括：胸腺、心脏、肺、肝、睾丸、肾 … Web036577 B6.129S6(Cg)- Ptf1a tm2(cre/ESR1)Cvw /J The Ptf1a Cre-ERTM knock-in allele was designed to both abolish pancreas specific transcription factor, 1a ( Ptf1a ) gene function …

WebMar 21, 2024 · We provide strong evidence for spatiotemporally context-dependent activity of Ptf1a as a potent gain-of-function trigger of pro-pancreatic commitment. Data suggest the role of pancreas-specific transcription factor 1a (PTF1a) in pancreas development in directing differentiation of embryonic stem cells (ESCs) to endocrine cells.

WebCreERT2重组酶的活性特异表达在胰腺腺泡，有少量细胞漏表达；在小脑、垂体和胃粘膜下层有极少量细胞表达。未检测到表达的组织包括：胸腺、心脏、肺、肝、睾丸、肾、小肠 … export music to ipodhttp://www.informatics.jax.org/allele/MGI:6758049 export music to mac miniWebThe results confirm the presence of multipotent ptf1a‐expressing progenitor cells in developing zebrafish pancreas, with reduced pTF1a dosage promoting greater contributions towards non‐acinar lineages and underscoring the central role of p TF1a in foregut tissue specification. Background: Pancreas development in zebrafish shares many features with … export my anime listWebLowell, MA. $45. 1989 80+ Baseball Cards Topps Rookies and stars- Randy Johson, Gary Sheffield, Rose, Clemens, Pucket. Ipswich, MA. $299. Samsung Galaxy S 21 5G 128 GB … bubbles out of characterWebJul 7, 2015 · The protein PTF1A is crucial for establishing the differentiation state of acinar cells. In the most common form of pancreatic cancer, acinar cells are reprogrammed to … export music to ipadWebPlasmid p-EF1a-CreERT2-3Xflag-T2A-eBFP2 from Dr. Bradley Bernstein's lab contains the insert CreERT2-T2A-eBFP2 and is published in Cell Rep. 2024 Oct 6;33(1):108222. doi: … export mxd to qgisWebEgfr f/f ;Ptf1a FlpO/+ ;FSF-Rosa26 CAG-CreERT2 mice allow conditional deletion of EGFR in pancreatic epithelial cells in a timely manner by the administration of tamoxifen (Wen et … bubbles outdoor games outdoor toys toys