Shoc2 uniprot

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August undefined, 2024

WebSHOC2-003: 815: No protein- Gene/transcript that doesn't contain an open reading frame (ORF). Processed transcript---ENST00000489783.1: SHOC2-004: 749: ... Uniprot. This transcript corresponds to the following Uniprot identifiers: Q9UQ13. CCDS. This transcript is a member of the Human CCDS set: CCDS7568. Version. ENST00000369452.4. Web1 Dec 2001 · UniProt is a GBC global core biodata resource Main funding by: National Institutes of Health We'd like to inform you that we have updated our Privacy Notice to …

Transcript: ENST00000369452.4 (SHOC2-001) - Summary

WebDephosphorylation of Ser-259 by the complex containing protein phosphatase 1, SHOC2 and M-Ras/MRAS relieves inactivation, leading to stimulate RAF1 activity. Phosphorylation at … WebSHOC2 Approved name SHOC2 leucine rich repeat scaffold protein Locus type gene with protein product HGNC ID HGNC:15454 Symbol status Approved Previous names soc-2 (suppressor of clear, C.elegans) homolog soc-2 suppressor of clear homolog (C. elegans) SHOC2 leucine-rich repeat scaffold protein SHOC2, leucine rich repeat scaffold protein اعلام برنامه شبکه mitv

Structure–function analysis of the SHOC2–MRAS–PP1C …

WebSHOC2 10:110919367-111017307. Forward strand gene: SHOC2 leucine rich repeat scaffold protein Also known as: SUR8, SOC-2, SUR-8, SOC2, KIAA0862, ... Show more Source: UniProt. DECIPHER holds 10 sequence variants in this gene, in 10 open-access patients Overview Web29 Sep 2024 · Assembly of the SHOC2–MRAS–PP1CA complex. We purified the pre-assembled human SMP complex by co-expressing SHOC2, MRAS (MRAS-Q71L or wild type (WT)), and PP1CA from a single plasmid (Fig. 1a ... WebWelcome to ProteomicsDB! ProteomicsDB is an effort of the Technische Universität München (TUM). It is dedicated to expedite the identification of the human proteome and its use across the scientific community. crtani sa prevodom slugterra

Q9UQ13 SWISS-MODEL Repository

Web21 Mar 2024 · SHOC2 (SHOC2 Leucine Rich Repeat Scaffold Protein) is a Protein Coding gene. Diseases associated with SHOC2 include Noonan Syndrome-Like Disorder With … WebResearch studies have demonstrated that SHOC2 forms a complex with the catalytic subunit of the PP1 phosphatase and M-Ras, and this complex drives activation of Raf-ERK signaling in response to mitogenic growth factors (1). SHOC2 has also been shown to cross-talk with and activate the PI3K/Akt signaling axis through its interaction with the ... اعلام برنامه شبکه iccWeb4 May 2024 · To study SHOC2 function in adult tissue homeostasis, SHOC2 KO and KI mice were crossed with animals carrying an inducible ubiquitously expressed CreERT2 recombinase (R26-CreERT2). Treatment with tamoxifen leads to efficient recombination (>80%) in all tissues examined except brain. Significantly, SHOC2 inactivation is tolerated … اعلام برنامه شبکه tv8

"Web Transcripts that don't contain an open reading frame (ORF) and cannot be placed in one of the other categories. " - Shoc2 uniprot

Shoc2 uniprot

Web16 Aug 2004 · UniProt is a GBC global core biodata resource Main funding by: National Institutes of Health We'd like to inform you that we have updated our Privacy Notice to … Web13 Jul 2024 · A structure of the MRAS–SHOC2–PP1C complex supports a RAS-driven and multi-molecular model for RAF activation in which individual RAS–GTP molecules recruit RAF–14-3-3 and SHOC2–PP1C to ...

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Web5 Nov 2024 · Studies over the past decade have uncovered the critical role of the Shoc2 scaffold in the transmission of signals through the core ERK1/2 cascade (Jang et al., 2024).These studies convincingly demonstrated that this seemingly auxiliary component of the ERK1/2 signaling network is an indispensable regulator of the ERK1/2 pathway, as its … WebSHOC2 Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, SHOC2 Genome Browser, SHOC2 References. ... UniProt Q9UQ13 Pfam Q9UQ13 Atlas Genetic Oncology n/a HGNC 15454. Drug resistance. This section shows the drugs associated with SHOC2 resistance mutations. In the tabs below you can see any other genes that have ...

WebFull gene name according to HGNC. SHOC2 leucine rich repeat scaffold protein. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to … WebSubcellular - SHOC2 - The Human Protein Atlas SUMMARY TISSUE BRAIN SINGLE CELL TISSUE CELL PATHOLOGY DISEASE IMMUNE BLOOD SUBCELL CELL LINE SHOC2 SUBCELLULAR RNA EXPRESSION HUMAN CELLS MOUSE CELLS ANTIBODIES AND VALIDATION Dictionary Cytosol Nucleoplasm Subcellular proteome Cytosol Nucleoplasm

WebRegulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. This gene encodes a protein that consists …

WebDetect Leucine-rich repeat protein SHOC-2 using this rabbit polyclonal antibody, Anti-SHOC2 Antibody validated for use in western blotting & IHC. - Find MSDS or SDS, a COA, data sheets and more information. ... UniProt Number: Q9UQ13; Molecular Weight ~65 kDa observed. Uniprot describes 2 isoforms at ~60 kDa and ~65 kDa. Uncharacterized bands ... crtani sa slonovimaWeb26 Mar 2024 · The non-injected and WT Shoc2-injected embryos showed an almost perfect spherical shape, whereas embryos injected with the RASopathy-associated Shoc2 mutants appeared oval-shaped . The major-to-minor axis ratio was significantly increased in all embryos expressing the pathogenic variants, compared to what was observed in WT … اعلام برنامه های tv8WebSHOC2 localizes to cytoplasm when inactive but rapidly translocates to the nucleus when activated, such as during growth factor stimulation. Thus, as expected, SHOC2 also participates in FGF receptor signaling. ... Uniprot describes 2 isoforms at ~60 kDa and ~65 kDa Uncharacterized bands may appear in some lysate(s). Physical form. اعلام برنامه کانال tv8WebUniProt is a GBC global core biodata resource Main funding by: National Institutes of Health We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s … اعلام برنامه های بی بی سی فارسیUniProt is a GBC global core biodata resource Main funding by: National Institutes of Health We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2024. See more This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. 1. Name1 2. See … See more اعلام برنامه های شبکه onyxWebUniProt website fallback message If you are not seeing anything on this page, it might be for multiple reasons: You might have JavaScript disabled: make sure to ... crtani sa zmajevimaWeb4 Feb 2024 · SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and … اعلام برنامه های tv24